The use of antibodies have revolutionized biochemistry, biotech and pharmaceutical industries. As such it is a class of proteins that have attracted a tremendous interest and are the focus of much characterization. To follow the stability, aggregation, degradation and interactions of antibodies in various formulations, model systems and complex matrices are therefore of high interest.
At SOLVE we work with antibodies in all stages, from early discovery phase, through formulation and process development to quality control, toxicological and clinical stages. With the techniques at our disposal it is possible to monitor not only the antibody but also antibody complexes and antibody conjugates.
A few examples of using different techniques for antibody characterization are given below:
1) DLS of antibody, reference and client candidate
2) AF4-UV of stressed antibody showing both degradation and aggregation
3) AF4 of ADA or ADC