During early pharmaceutical development it may be that several candidates need to be screened for different properties. Also it may be that a large number of different solutions with varying compositions may need to be tested. At SOLVE we screen using the various techniques at our disposal. One of the most suitable techniques for reasons of time and sample volumes is DLS in high-throughput plate format. We also advice that such test are conduced according to design of experiments (DOE) which fits well with a quality by design (QBD) approach which is often recommended. It may be prudent to further characterize hit candidates or conditions using methodologies such as SEC-MALS, AF4-MALS or AUC to validate the results from the screening in a second step after the screenings.