For many products, the size and molar mass distributions have a huge impact. Size and molar mass may affect the viscosity of solutions, the adsorption properties, influence uptake, and many other properties. For technical applications, it is often needed to control the presence of microgels or particulates in samples. They may otherwise interfere with the functionality or the visual properties of the product. At SOLVE we use DLS, SEC-MALS, AF4-MALS, and AUC to determine size and molar mass distributions. We work with everything from small peptides and proteins, up to large polymers, polysaccharides, and nanoparticles. We are often approached with compounds that are challenging to characterize with standard analytical and physicochemical techniques.